 Arizona State University BioSafety
Program Manual
Table of Contents
Preface
Introduction and Scope
Regulatory Requirements and Guidelines
Select Agents and Toxins
Responsibilities
Biohazardous Research Project Registration and Approval
Introduction
Registration and Approval Process
Additional Approvals and Requirements
Select Agents and Toxins
Human Blood and Tissue
Animal Handling
Working Safely with Biohazardous Materials
Exposure Control
Laboratory Practice and Technique
Safety Equipment (Primary Barriers)
Facility Design (Secondary Barriers)
Laboratory Biosafety Levels
Animal Biosafety Levels
Laboratory Procedures and Equipment
Guidelines for Good Laboratory Practices at BSL1
Guidelines for Good Laboratory Practices at BSL2
Guidelines for Good Laboratory Practices at BSL3
Biological Safety Cabinets (BSC)
Types of BSCs
Guidelines for Working in a BSC
Certification of a BSC
Emergency Response Procedures
Decontamination
When to Decontaminate
Autoclave Use
Chemical Disinfectant Use
Exposure to Biohazardous Agents
Intact Skin
Broken, Cut, or Damaged Skin or Puncture Wound
Eye
Ingestion or Inhalation
Biological Material Spills
Spills Inside a BSC
Small Spill of Material Outside of a BSC
Large Spill of BSL2 Material Outside of a BSC
Biohazardous Agent and Toxin Waste Handling
Incident Reporting
Transfers, Packaging, and Shipping of Biological Materials
Transfers
Packaging
Packaging with Dry Ice
Labeling
Shipping and Transportation Methods and Requirements
Registered Mail or Equivalent
Federal Express or UPS
Damaged Packages
Notice of Delivery
Importation / Exportation of Etiologic Agent
Other Permits
Security
Audits and Compliance
Record Keeping
Program Evaluation
Related Documents and Plans
Table 1: Disinfectant Activity
Table 2: Disinfectant Characteristics
Table 3: Disinfectant Applications
Appendix A: Definitions
Appendix B: Biosafety Standard Operating Procedure
Required supporting documentation for the Biosafety SOP
Appendix B-1: Floor Diagram
Appendix B-2: Health Hazard Assessment
Appendix B-3: IBC Application Documentation
Appendix B-4: Suggested Format for Lab Biosafety Binder
Appendix C: Special Considerations for Select Agents and Toxins|
Appendix D: ASU Laboratory Security Guidance for Laboratories Working with Select Agents ........
Required supporting documentation for Appendix D
Appendix D-1: Threat Analysis Procedure and Worksheet
Appendix D-2: Commissioning Checklist
Appendix D-3: Select Agent Laboratory Inspection and Policy Review Checklist
Appendix D-4: Training and Documentation Form
Appendix D-5: Bioterrorism Preparedness and Response Act, FBI Information Form
Appendix D-6: USA Patriot Act Compliance Questionnaire
Appendix D-7: Lost Door Access Card Form
Appendix D-8: Key Inventory Log Form
Appendix D-9: Visitor Log
Appendix D-10: Inventory Control Log
Appendix D-11: Internal Destruction Form
Appendix D-12: ASU Emergency Procedures Flipchart
Appendix D-13: DPS Policies and Procedures Manual
Appendix D-14: Guidance Document for Report of Theft, Loss, or Release of Select Biological Agents and Toxins
Appendix D-15: Required contents for Biosafety Select Agents Binder
Mailing Address: PO Box 875412, Tempe, Arizona 85287-5412
Contact Email: EHS@asu.edu
Phone: (480) 965-1823
FAX: (480) 965-0736
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